Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6161-6164.doi: 10.3969/j.issn.1673-8225.2011.33.020

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Effects of modified acidic fibroblast growth factor on free radical and lipid peroxide in aging model rats

Huang Jun-jie1, Wang Cai-bing1, He Xian-jiao1, Huang Li-juan1, Huang Yan-feng1, Zhao Shan-min1, Li Qian-ming2, Huang Ju-en3   

  1. 1Department of Applied Physiology, Youjiang Medial College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China; 2Department of Physiology, 3Department of Histology and Embryology, Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-09 Revised:2011-07-09 Online:2011-08-13 Published:2011-08-13
  • About author:Huang Jun-jie★, Master, Associate professor, Department of Applied Physiology, Youjiang Medial College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China moke68@163.com
  • Supported by:

    Scientific Research Program of Education Department of Guangxi Zhuang Autonomous Region, No.Guikejiaoyan[2007]34(200707LX136)*

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Abstract:

BACKGROUND: Several studies have demonstrated that modified acidic fibroblast growth factor (maFGF) is a multifunctional growth factor, but its anti-aging effects have not been reported.
OBJECTIVE: To investigate the effects of maFGF on superoxide dismutase (SOD), malondialdehyde (MDA) and hydroxyl radical ability in cerebral cortex, liver tissue and serum of subacute aging model rats.
METHODS: Adult Wistar rats were established into aging models by subcutaneous injection of D-galactose. Then aging rat models were assigned to three groups: model, saline control, maFGF. A normal control group was set. The maFGF group rats were intramuscularly injected with 12 µg/kg maFGF. The saline control group was intramuscularly injected with the same amount of saline. The model group rats did not receive any intervention.
RESULTS AND CONCLUSION: Compared with model and saline control groups, SOD activity and hydroxyl radical ability in cerebral cortex, liver tissue and serum were significantly increased (P < 0.01 or P < 0.05), and MDA level was significantly decreased (P < 0.01 or P < 0.05) in the maFGF group. Results showed that maFGF decreases free radial level, enhances organism’s anti-aging ability, and thereby exhibiting anti-aging effects.

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