Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6127-6130.doi: 10.3969/j.issn.1673-8225.2011.33.012

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Feasibility to establish a mini-pig model of class II furcation defect

Chen Shan, Yang Jun-ying, Zhang Sheng-yan, Feng Lei   

  1. Department of Stomatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou   510080, Guangdong Province, China
  • Received:2011-04-06 Revised:2011-07-18 Online:2011-08-13 Published:2011-08-13
  • Contact: Yang Jun-ying, Master, Associate professor, Department of Stomatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China aliceyang2006@ 126.com
  • About author:Chen Shan★, Master, Physician, Department of Stomatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China chenshan00001@ 163.com
  • Supported by:

    Science and Technology Plan Program of Guangdong Province, No.2009B060700042*

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Abstract:

BACKGROUND: The premise of an effective evaluation of periodontal tissue regeneration is to successfully establish alveolar bone defect model. Most of previous studies use dogs as experimental animals, but the operation is more difficult.
OBJECTIVE: To investigate the possibility of establishing an animal model of class Ⅱ furcation defect in mini-pigs.
METHODS: Mini-pig models of class Ⅱ furcation defect were prepared. The model group did not receive any agents while the control group was weekly injected with 2.2 mg simvastatin/methylcellulose gel.
RESULTS AND CONCLUSION: Eight weeks later, gross and pathological observation showed that it was empty in the defects of the model group and new bone was found in the control group. Mature fibrous tissue and proliferative vessels as well as a large number of osteoblasts and osteocytes were observed in the control group, while little new bone, proliferative vessels and a small number of osteoblasts were observed in the model group. These results showed that it is feasible to establish class Ⅱ furcation defect in mini-pigs.

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