Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6124-6126.doi: 10.3969/j.issn.1673-8225.2011.33.011

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Establishment and evaluation of nonalcoholic fatty liver disease model in New Zealand rabbits

Ji Rong1, Tang Li2   

  1. 1Department of Infectious Disease, First Affiliated Hospital of Medical School of Shihezi University, Shihezi  832008, Xinjiang Uygur Autonomous Region, China
    2Department of Infectious Disease, First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-05-13 Revised:2011-07-07 Online:2011-08-13 Published:2011-08-13
  • About author:Ji Rong, Master, Associate chief physician, Department of Infectious Disease, First Affiliated Hospital of Medical School of Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China jirong@sina.cnjirong@sina.cn

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Abstract:

BACKGROUND: Fat-rich diet is an independent risk factor of nonalcolholic fatty liver disease.
OBJECTIVE: To establish a rabbit model of nonalcolholic fatty liver disease.
METHODS: New Zealand rabbits were randomly divided into a control group and a model group. The model group rabbits were given fat-rich diet and the control group rabbits were given standard diet.
RESULTS AND CONCLUSION: After raise for 12 weeks, hepatocytes of the model group rabbits developed diffuse fatty degeneration, inflammatory cell infiltration, necrosis and fibrosis were observed in the portal area and lobules. Abnormal liver was not observed in the control group. Liver index (liver weight/weight×100%), serum alanine aminotransferase, aspartate aminotransferase, and triacylglycerol levels were significantly higher in the model group than in the control group (P < 0.01 or P < 0.05). These results showed that a rabbit model of nonalcolholic fatty liver disease was successfully established.

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