Abstract:

BACKGROUND: Recent studies have shown that osteoporosis incidence is higher in hypertension patients than in healthy population.
OBJECTIVE: To investigate the relationship between primary hypertension and mandible resorption.
METHODS: Primary hypertension rats were randomly divided into a model group and an administration group. Normal rats served as controls. The model and control group rats were given standard animal feeds without hypotensive drugs. The administration group rats were given standard animal feeds with hypotensive drugs.
RESULTS AND CONCLUSION: The blood pressure of model group rats was gradually increased from 10-22 weeks and tended to stable after 22 weeks. The blood pressure of the administration and control groups was low and stable. For the same age rats, the blood pressure was highest in the model group, followed by the administration group, and lastly the control group (P < 0.01). Mandible mass was significantly lower in the model and administration groups than in the control group (P < 0.01). In the model group, the cortical bone was thinner, with sparse, thin or broken trabecula and bone marrow cavity was enlarged. The pathological changes were alleviated in the administration group than in the model group. Results showed increased blood pressure can cause mandible reduction of rats with primary hypertension, which causes thinned and disordered bone trabecula and then increases the risk of frontal resorption.