Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6090-6094.doi: 10.3969/j.issn.1673-8225.2011.33.003

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Construction of protein-protein interaction network of osteoporosis and prediction of pathways underlying molecular complexes

Zhang Zhi-guo1, Niu Xu-yan2, Liu Mei-jie1, Li Yan1, Lu Ai-ping2, Ju Da-hong1   

  1. 1Institute of Basic Theory on TCM, 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (CACMS), Beijing  100700, China
  • Received:2011-02-04 Revised:2011-03-25 Online:2011-08-13 Published:2011-08-13
  • Contact: Ju Da-hong, Doctor, Researcher, Institute of Basic Theory on TCM, China Academy of Chinese Medical Sciences (CACMS), Beijing 100700, China judahong@sohu.com
  • About author:Zhang Zhi-guo☆, Doctor, Assistant researcher, Institute of Basic Theory on TCM, China Academy of Chinese Medical Sciences (CACMS), Beijing 100700, China Zzgtcm@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30973691*; the China Postdoctoral Science Foundation, No. 20100470524*

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Abstract:

BACKGROUND: Based on the protein-protein interaction network, the mechanism of osteoporosis can be understood more deeply and comprehensively.
OBJECTIVE: To develop a protein-protein interaction network of osteoporosis based on genetic genes and to predict pathways underlying the molecular complexes in the network.
METHODS: Genetic genes of osteoporosis were screened from OMIM database; literature mining for the genes was realized by Agilent Literature Search plugin, protein-protein interaction network of osteoporosis was established by Cytoscape, the molecular complexes in the network were detected by Clusterviz plugin and the pathways enrichment of molecular complexes were realized by DAVID online.
RESULTS AND CONCLUSION: The protein-protein interaction network of osteoporosis contained 863 nodes, 2 925 edges and 4 molecular complexes. Pathways underlying complexes 3 involved immunological cell surface molecular adhesion, cytokines-receptor binding, hematopiesis and hemostasis; complexes 4 had relation to diabetes mellitus.

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