Abstract:

BACKGROUND: How to use the adhesion of fibrin glue to combine with autologous bone marrow and artificial bone to increase the success rate of spinal fusion in surgery, it is worthy of further study.
OBJECTIVE: To review the research background, composition, function theory, physical and chemical properties of fibrin glue, the present of fibrin glue, autologous bone marrow combined with artificial bone in spinal fusion.
METHODS: China Knowledge Resources Library-CNKI Series Database (1994 to 2010) and PubMed database were retrieved by the first author for literatures concerning the research background, composition, function theory and physical and chemical properties of fibrin glue, the application of fibrin glue in bone tissue engineering and repairing bone defects, the application of autologous bone marrow graft combined with artificial bone transplantation in repairing bone defects, the application of bone graft methods of spinal fusion.
RESULTS AND CONCLUSION: Autologous bone marrow graft combined with artificial bone repairing bone defects achieved good clinical efficacy. Therefore, it should be a feasible solution which using autologous bone marrow combined with artificial bone to increase spinal fusion rate in spinal fusion. However, the process of autologous bone marrow combined with artificial bone was relatively simple in the past. Because of a large fluidity of autologous bone marrow, it lost easily after injection, and reduced its bone formation function. Therefore, it is envisaged in clinical surgery that the adhesion properties of fibrin glue were used to adhere autologous bone marrow and artificial bone together, implant it in spinal zygapophysial joints and transverse process and make full use of its largest bone formation function. This will be a simple, fast and effective clinical way for increasing spinal fusion rate. It needs to be further researched.