Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (16): 2901-2904.doi: 10.3969/j.issn.1673-8225.2011.16.012

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Biocompatibility of calcium-titanate coating prepared by thermochemical treatment

Huang Jing1, Lan Lin1, Xiao Dong-qin1, Luo Hui-tao1, Zhi Wei1, Duan Ke1, Weng Jie1, Zhang Cong2   

  1. 1Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu  610031, Sichuan Province, China
    2the 452 Hospital of Chinese PLA, Chengdu  610021, Sichuan Province, China
  • Received:2010-09-25 Revised:2010-11-24 Online:2011-04-16 Published:2013-11-11
  • Contact: Zhang Cong, Professor, Doctoral supervisor, Chief physician, the 452 Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China Cong60@ hotmail.com
  • About author:Huang Jing★, Studying for master’s degree, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan Province, China huangjing318@yahoo.cn
  • Supported by:

     the National Natural Science Foundation of China, No. 30870630*, 81071456*; the Tackle Key Problems in Science and Technology during the “Elenven- Five-year Plan”, No. 06G049*; the Starting Item for Science and Technology Research of Young Teachers in Southwest Jiaotong University, No. 209Q007*

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Abstract:

BACKGROUND: Calcium-titanate (CaTiO3) is a promising coating candidate on titanium biomedical implants.
OBJECTIVE: To prepare uniform CaTiO3 coatings on Ti6Al4V substrates by a simple thermochemical surface transformation technique and to evaluate its biocompatibility by in vitro culture of rat osteoblasts.
METHODS: Ti6Al4V substrates were embedded in anhydrous calcium nitrate powders and the temperature was increased; reaction between the molten nitrate and Ti6Al4V formed a uniform layer of calcium nitrate. The biocompatibility of Ti6Al4V thermochemically treated at 570 ℃ was evaluted by in vitro culture of SD rat osteoblasts.
RESULTS AND CONCLUSION: The transformation occurred only above the melting point of anhydrous calcium nitrate (561℃), and that the size of the calcium titanate crystals increased with the treatment temperature. Proliferation and adhesion of osteoblasts was promoted on the thermochemically treated substrates. This technique is simple and efficient, and may find applications in the surface processing of titanium implants and improve. the biocompatibility between metals and cells or tissues.

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