Abstract:

BACKGROUND: Parkinson disease in the elderly has become a common movement disorders, currently its main form of treatment is still in the fields of medicine and surgery, and the role of neural stem cells in functional recovery in Parkinson's disease has been domestic and foreign scholars’ attention.
OBJECTIVE: To explore the effect of neural stem cells on Parkinson disease based on the analysis of biological characteristics of neural stem cells and pathological features of Parkinson disease, in order to provide a scientific basis for rehabilitation of Parkinson disease promoted by neural stem cells transplantation.
METHODS: A computer based online search of Medline database, CNKI database and VIP database (1994-01/2010-08) was performed with the key words of "Parkinson disease, neural stem cell, rehabilitation" in English and Chinese, respectively. According to the relevant literature of Parkinson disease and neural stem cells, articles published in recent years or in authorized journals were included. Duplicated and outdated articles were excluded. The standard literatures were involved for analysis.
RESULTS AND CONCLUSION: Through research we found that neural stem cells in the rehabilitation of patients with Parkinson disease have many advantages, such as their materials can be easily obtained, low immunogenicity and orientable differentiation. Neural stem cells transplantation has been served as a treatment for nerve damage, including Parkinson disease. But if neural stem cells are applied to clinical treatment, it is still need to be constantly researched. The differentiation and mechanisms of functional repair in neural stem cells are unclear. Whether cells can be integrated with injury in vivo after transplantation to establish normal synaptic connections also need to be further studied.