Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (14): 2633-2636.doi: 10.3969/j.issn.1673-8225.2011.14.036

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Strategy study of treatment for cerebral infarction sequelae using neural stem cell transplantation

Chen Xiao-yu1, Duan Yun-xia1, Fang Liang2, Zhang Zi-qian1, Liu Qing-shan1   

  1. 1Ethnic Minority Study Center of China, Minzu University of China, Beijing  100081, China
    2College of Physical Education, Soochow University, Suzhou  215021, Jiangsu Province, China
  • Received:2010-11-02 Revised:2011-01-17 Online:2011-04-02 Published:2013-11-02
  • Contact: Liu Qing-shan, Doctor, Master’s supervisor, Ethnic Minority Study Center of China, Minzu University of China, Beijing 100081, China
  • About author:Chen Xiao-yu★, Studying for master’s degree, Ethnic Minority Study Center of China, Minzu University of China, Beijing 100081, China xiaoyu0767@163.com
  • Supported by:

    the National Natural Science Foundation of China (General Program), No. 30973959*, 20962012*; the Independent Science Research Item of Minzu University of China, no. 0910KYXJ12*; the Cultivation of Innovative Talents of Minzu University of China, No. 0212110309100435*

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Abstract:

BACKGROUND: Studies have demonstrated that stem cell transplantation plays a positive role in treatment of cerebral infarction, which also has good outcome in recovery and diminution of infarct size in clinical trials. 
OBJECTIVE: By analyzing and summarizing the research which adopts treatment of cerebral infarction sequelae in past ten years, we devote to discuss the strength and weakness of those treatments and find a suitable treatment of cerebral infarction sequelae.
METHODS: Application of computer technology to retrieve the articles in wanfang data and PubMed database on spinal cord tissue engineering from 2000 January to 2010 October. Words for retrieve were “cerebral infarction sequelae, neural stem cells”.  Twenty-two literatures were remained for analysis.
RESULTS AND CONCLUSION: Neural stem cell transplantation for treating cerebral infarction sequelae are focus on integration, supplementation, or substitution damaged cells by transplanting exogenous neural stem cells, activation or repair injured endogenous neural stem cells. Neuroprotection aims directly at various passageways during ischemic cascade reactions, protects neurons which damaged by ischemia or hypoxia but has viable to reverse ischemic penumbra, decreases reperfusion injury, and reduces infarct size. Applications of physical therapy, functional rehabilitation and ethnic medicine provide new hope for treatment of cerebral infarction sequelae. How to regulate proliferation and differentiation of neural stem cells in vivo and promote neurologic repair is the research focus.

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