Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (13): 2403-2407.doi: 10.3969/j.issn.1673-8225.2011.13.029

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Effect of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1: A Gabor wavelet and Hilbert transform study

Dong Guo-ya1, Chen Xiao-gang1, Zhou Xin-hua2, Li Wen-wen1, Ge Man-ling1   

  1. 1Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin  300130, China
    2Department of Marine Engineering, Hebei Jiaotong Vocational and Technical College, Tianjin  300381, China
  • Received:2010-11-03 Revised:2010-12-15 Online:2011-03-26 Published:2013-10-23
  • About author:Dong Guo-ya☆, Doctor, Associate professor, Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China dongguoya@gmail. com
  • Supported by:

    the Natural Science Foundation of Hebei Province, No. E2009000062*, E2010000053*

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Abstract:

BACKGROUND: Theta oscillation is a representative characteristic of neural activity in hippocampus and serves as the starting point for the study of epilepsy and cognition in micro-ways.
OBJECTIVE: To investigate the effects of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1.
METHODS: The iEEG data of 8 epileptic rats and 10 patients from School of Medicine, Mediterranean University, Marseilles, France were collected, and their corresponding iEEG data without spike and waves as controls. Gabor wavelet and Hilbert transform were used for extraction of the power of theta oscillation before and after the spike waves. The outcomes of Gabor wavelet and Hilbert transform were compared.
RESULTS AND CONCLUSION: Dynamic characteristics of theta power in epilepsy group: Epileptic interictal spike and waves weaken the theta oscillation power, but after a long period of spike and waves, theta oscillation power recovered. It is speculated that the brain's default network connection strength is affected by status epilepticus and may be weakened. However, the weakening of the default network is a pathological basis of cognitive decline.

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