Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (13): 2366-2370.doi: 10.3969/j.issn.1673-8225.2011.13.021

Previous Articles     Next Articles

Vertebroplasty injected with bone cement versus non-operative treatment for osteoporotic vertebral compression fractures: A Meta-analysis

Xu Jian-cheng1, Bai Jing-ping1, Xilin Baoleri1, He Zu-sheng1, Jiang Ren-bing1, Huang Wei-min2   

  1. 1Department of Orthopaedics, Tumor Hospital of Xinjiang Medical University, Urumqi  830011, Xinjiang Uygur Autonomous Region, China
    2Department of Spine Surgery, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi  830011, Xinjiang Uygur Autonomous Region, China
  • Received:2010-11-21 Revised:2010-12-30 Online:2011-03-26 Published:2013-10-23
  • Contact: Bai Jing-ping, Professor, Doctoral supervisor, Department of Orthopaedics, Tumor Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China 08xjc@sina.com
  • About author:Xu Jian-cheng★, Studying for master’s degree, Department of Orthopaedics, Tumor Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China 08xjc@sina.com

PDF

674

Abstract:

BACKGROUND: Vertebroplasty injected with bone cement or percutaneous vertebroplasty as the minimally invasive technique in treatment of osteoporotic vertebral compression fracture. Some case reports and non-randomized controlled study revealed that vertebroplasty has an effect on pain caused by osteoporotic vertebral compression fractures. However, these studies are based on retrospective case analysis, lack of high-quality randomized controlled study.
OBJECTIVE: To evaluate the effectiveness of Meta-analysis method on vertebroplasty versus non-operative in treatment of osteoporotic vertebral compression fractures.
METHODS: A computer-based online search of Cochrane Library (the 4th period, 2010), PubMed database (1966/2011-11), EMBASE database (1974/2010-11), CBM database (1978/2010-11), CNKI database (1994/2010-11), and Wanfang database (1997/2010-11). Randomized controlled trials of vertebroplasty versus non-operative in treatment of osteoporotic vertebral compression fractures were included, and underwent strict quality assessment according to Cochrane Handbook 5.0. Meta-analysis was performed by RevMan 5.0.1 software.
RESULTS AND CONCLUSION: A total of 445 cases in 4 randomized controlled trials were included. Meta-analysis results showed that vertebroplasty in pain relief is more obvious than that in conservative treatment at 1, 4, 24, 48 weeks follow-up, but there were no significant differences in incidence of new fracture between the two groups. Compared with the placebo, there is no significant advantage for the vertebroplasty over the placebo in pain relief, the improvement of functional activities of waist, and quality of life. The above conclusions still needs more high-quality randomized controlled trails to be verified owing to the limitations of the number and quality of systematic review included studies.

CLC Number: