Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 2051-2054.doi: 10.3969/j.issn.1673-8225.2011.11.038

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Progress addressing animal stress model construction and effect evaluation

Na Qin1, Cheng Biao2, Chen A-mei1   

  1. 1Department of Histology and Embryology, Inner Monglia Medical College, Huhhot  010059, Inner Monglia Autonomous Region, China
    2Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou  510010, Guangdong Province, China
  • Received:2010-09-10 Revised:2010-10-25 Online:2011-03-12 Published:2011-03-12
  • Contact: Cheng Biao, Doctor, Professor, Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China chengbiaocheng@ 163.com Chen A-mei, Master, Professor, Department of Histology and Embryology, Inner Monglia Medical College, Huhhot 010059, Inner Monglia Autonomous Region, China
  • About author:Na Qin★, Studying for master’s degree, Department of Histology and Embryology, Inner Monglia Medical College, Huhhot 010059, Inner Monglia Autonomous Region, China 752170727@qq.com
  • Supported by:

    the General Program of Military Medical Sciences Plan during the Eleventh Five-Year plan, No. 08G027*

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Abstract:

BACKGROUND: People are paying close attention to the relationship between stress and disease. Establishment of animal stress models is the basic for stress research, which is lack of united standard. 
OBJECTIVE: To introduce animal model construction methods and effect evaluation, in addition, to analyze existing problems during model preparation.
METHODS: A computer-based online search was performed using key words of “stress, animal model, murine, and evaluate” for documents on VIP and PuMed from 2000 to 2010. Repetitive papers were excluded. 
RESULTS AND CONCLUSION: A total of 417 documents were collected, including 115 in Chinese and 302 in English. By reading titles and abstract, 30 papers were included in the final analysis. Currently, various animal stress models are involved, but there is not a unified standard, and the stress degree remains lack of quantizatable index. With rapidly development of neuroscience, molecular biology, and electrophysiology, the stress research is extended into molecular level and integrated network. The wide application of transgenic technology, gene knockout models, and protein depletion provide new approach for study of stress mechanism.

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