Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 2047-2050.doi: 10.3969/j.issn.1673-8225.2011.11.037

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Repair of articular cartilages and relevant cytokines

Shi Xin-li1, Hu Kun2, Meng Xiang-ti2   

  1. 1Center for Medical Device Evaluation, State Food and Drug Administration, Beijing  100044, China
    2Institute of Nuclear and New Energy Technology of Tsinghua University, Beijing  100084, China
  • Received:2010-10-14 Revised:2011-01-29 Online:2011-03-12 Published:2011-03-12
  • Contact: Hu Kun, Doctor, Senior engineer, Institute of Nuclear and New Energy Technology of Tsinghua University, Beijing 100084, China hukun@tsinghua. edu.cn
  • About author:Shi Xin-li, Senior engineer, Center for Medical Device Evaluation, State Food and Drug Administration, Beijing 100044, China sci@allgensmed. com

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Abstract:

BACKGROUND: Articular cartilages injuries are hard to repair completely, easily present with degenerative changes under physiological stress, and develop into osteoarthritis. It provides a new approach for the treatment of osteoarthritis using tissue-engineered cartilages to repair damaged articular cartilages. 
OBJECTIVE: To overall understand the features of cytokines and construction of tissue-engineered cartilages similar to normal articular cartilage, and to identify the research process addressing promotive effect of cytokines on cartilage differentiation.
METHODS: Chinese Biomedical Literature Database and Medline database were searched by computer for reviews and reports concerning repair of articular cartilages and cytokines, and the research process was analyzed.
RESULTS AND CONCLUSION: Totally 29 documents were included. The repair of articular cartilage after damage is very limited, and its reaction to the wound and inflammation is mediated by cartilage cells and synovial tissues or cytokines in the joint fluids. Growth factors in chondrocyte matrix play an important role in cartilage growth and differentiation via regulating cell signal pathway; in addition, surrounding environment of chondrocyte also affects regulating cell differentiation.

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