Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 1965-1968.doi: 10.3969/j.issn.1673-8225.2011.11.016

Previous Articles     Next Articles

Influence of ultraviolet light A on epidermal growth factor receptor expression in fibroblasts in vitro

Liu Yin1, Liu Liu1, Wang Ji-hua2, Lu Kai-hua3, Wu Shang-min4, Yang Rui-nian1, Long Ting-feng1, Yuan Rui-hong1   

  1. 1Department of Plastic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming  650032, Yunnan Province, China
    2Department of Plastic Surgery, the Second Affiliated Hospital of Kunming Medical University, Kunming  650101, Yunnan Province, China
    3Department of Plastic Surgery, the First Affiliated Hospital of Fourth Military Medical University, Xi’an  710032, Shaanxi Province, China
    4Department of Plastic Surgery, the First People’s Hospital of Kunming, Kunming  650011, Yunnan Province, China
  • Received:2011-01-04 Revised:2011-02-02 Online:2011-03-12 Published:2011-03-12
  • Contact: Liu Liu, Doctor, Professor, Doctoral supervisor, Department of Plastic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • About author:Liu Yin☆, Studying for doctorate, Physician, Department of Plastic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China liuyinsky@163.com
  • Supported by:

    the Natural Sciences Foundation General Projects of Yunnan Province, No. 2004C0047M*

PDF

525

Abstract:

BACKGROUND: Ultraviolet A has a close relationship with skin photoaging, which impact on epidermis and dermis.
OBJECTIVE: To explore the influence of ultraviolet A on the epidermal growth factor receptor expression of human skin fibroblasts in vitro.
METHODS: Adult’s fibroblasts were divided into the control and ultraviolet A irradiation (5, 10, 20 J/cm2) groups. The epidermal growth factor receptor mRNA and protein were detected by real-time PCR and Western blot.
RESULTS AND CONCLUSION: The epidermal growth factor receptor mRNA and protein levels had upgraded as the dose of ultraviolet A irradiation increased. It suggests that ultraviolet A can lead to epidermal growth factor receptor expression in fibroblasts.

CLC Number: