Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 1929-1932.doi: 10.3969/j.issn.1673-8225.2011.11.007

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Interventional effect of Tongluo Shenggu capsules on expression of p38 signal pathway in stress absence induced osteoporosis rats

Liu Shao-jun1, Zhang Xian2, Feng Li-min2, Chen Xiao-jun1   

  1. 1First Department of Orthopedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou  510407, Guangdong Province, China; 2Central Laboratory, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou  510006, Guangdong Province, China
  • Received:2010-10-12 Revised:2010-12-11 Online:2011-03-12 Published:2011-03-12
  • About author:Liu Shao-jun☆, Doctor, Associate chief physician, Master’s supervisor, First Department of Orthopedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510407, Guangdong Province, China lioshaojun@163.net
  • Supported by:

    the grant from the Science and Technology Commission of Guangdong Province, No. 2007B031407010*

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Abstract:

BACKGROUND: Stress absence is the main reason for osteoporosis in insufficient exercises people. Tongluo Shenggu capsules can promote bone formation, however, its effect on p38 signal pathway remains poorly understood. 
OBJECTIVE: To investigate the influence of stress absence on p38 expression and the intervention of the Tongluo Shenggu capsules.
METHODS: A total of 40 SD rats were randomly divided into four groups. Exception those in the normal control group, all animals were subjected to tail suspension test for preparing stress absence models. Animals in the drug groups were administrated Tongluo Shenggu capsules (0.6 or 1.2 g/kg) once per day. After model preparation, animals were sacrificed and bones of lower leg were observed. The p38 protein level was determined by Western blot.
RESULTS AND CONCLUSION: Compared with the normal control group, the area and thickness of bone tranecula, the amount of osteoblast were decreased obviously in the model group; stress absence induced an increase of the total p38, but had little influence to the amount of phosphorylation p38. High-dose Tongluo Shenggu capsules increased the phosphorylation p38, while low-dose decreased the amount of phosphorylation p38. Stress absence induces osteoporosis, but high-dose Tongluo Shenggu capsules can prevent from osteoporosis via enhancing expression of p38.

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