Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (10): 1847-1850.doi: 10.3969/j.issn.1673-8225.2011.10.030

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Chinese herbs for inducing osteogenic differentiation of bone marrow mesenchymal stem cells 

Yang Feng1, Tang De-zhi2, Bian Qin2, Wang Yong-jun1, 2, Shi Qi1, 2   

  1. 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai  200032, China
    2Institute of Spine Disease, Shanghai University of Traditional Chinese Medicine, Shanghai  200032, China
  • Received:2010-10-27 Revised:2011-02-14 Online:2011-03-05 Published:2011-03-05
  • About author:Yang Feng☆, Studying for doctorate, Attending physician, Lecturer, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China yangfengdudu@163.com
  • Supported by:

    Major State Basic Research Development Program of China (973 Program), No. 2010CB30400*; National Natural Science Foundation of China, No. 30930111*; the Key Project of Shanghai Science and Technology Commission, No. 07JC14050*

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Abstract:

BACKGROUND: Some Chinese herbs can induce osteogenic differentiation of mesenchymal stem cells (MSCs). The potency of MSCs differentiate into osteogenesis has a theoretical communication with traditional Chinese medicine (TCM) treatment of osteoporosis, fractures, bone necrosis, bone defects and other bone-related diseases.
OBJECTIVE: To understand the researching status of osteogenic differentiation of MSCs induced by Chinese herbs so as to establish further researching foundation.
METHODS: CNKI database (2000-01/2010-06) and PubMed (2000-01/2010-06) were retrieved by the first author, with the key words of “Chinese herb, mesenchymal stem cells, osteogenic differentiation” in Chinese and in English. The literatures were limited to Chinese and English languages. Literatures concerning TCM monomer, single Chinese herb, Chinese herbal compound, and serum containing Chinese herb inducing osteogenic differentiation of MSCs in vivo and in vitro, human and animal were included. Repetitive studies were excluded.
RESULTS AND CONCLUSION: A total of 32 literatures were included, including 2 documents addressing research background of MSCs, 5 single Chinese herbs (4 kidney-nourished herbs and 1 Qi-nourished herb), 10 Chinese herbal compound (6 kidney-nourished formulas and 4 kidney-nourished and activating blood formulas), 15 effective components of Chinese medicine. The kidney-nourished Chinese herbs, Qi- nourished herbs and activating blood herbs can induce MSCs into osteogenic differentiation, but the kidney-nourished Chinese herbs are majority. It explores the scientific value of the theory of “kidney control bone” and supply more resources of seed cells for a large number of amplification of MSCs in vitro, osteogenic differentiation and bone tissue engineering.

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