Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (10): 1851-1854.doi: 10.3969/j.issn.1673-8225.2011.10.031

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Action and mechanism of umbilical cord blood stem cells transplantation for treatment of myocardial infarction 

Du Dan1, Zhang Ming2   

  1. 1Second Department of Cardiology, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
    2Department of Cardiology, Liaoning Province Jinqiu Hospital, Shenyang  110032, Liaoning Province, China
  • Received:2010-11-01 Revised:2010-12-20 Online:2011-03-05 Published:2011-03-05
  • Contact: Zhang Ming, Doctoral supervisor, Chief physician, Department of Cardiology, Liaoning Province Jinqiu Hospital, Shenyang 110032, Liaoning Province, China
  • About author:Du Dan★, Master, Physician, Second Department of Cardiology, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China doris346@163.com

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Abstract:

BACKGROUND: Many basic and clinical studies have demonstrated that stem cell transplantation can improve cardiac function in patients with heart failure following myocardial infarction.
OBJECTIVE: To summarize the action and mechanism of umbilical cord blood stem cells (UCBSCs) transplantation for treatment of myocardial infarction.
METHODS: The first author retrieved PubMed Database, CNKI and Wanfang Database for articles of basic research on UCBSCs transplantation for treating myocardial infarction published from 2000 to 2009.
RESULTS AND CONCLUSION: Stem cell transplantation for treating acute myocardial infarction exhibits advantages compared with traditional therapeutic method. A series of present basic researches have confirmed that human UCBSCs can be an ideal cell source, but these studies are in exploratory study stage and many problems should be solved, such as in vitro isolation and culture of human UCBSCs, optimal transplant therapeutic time, favorable transplant pathway, optimal transplant number, survival rate of transplanted cells, differentiation into myocardial cells or not posttransplantation, differentiation degree, therapeutic effects and safety.

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