Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (10): 1855-1858.doi: 10.3969/j.issn.1673-8225.2011.10.032

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Research and application of induced pluripotent stem cells in nervous system diseases

Li Jia-su1, Yao Zhong-xiang2   

  1. 1Squadron Four of Cadet Brigade, Third Military Medical University of Chinese PLA, Chongqing 400038, China
    2Department of Physiology, Basic Medical Department, Third Military Medical University of Chinese PLA, Chongqing 400038, China
  • Received:2010-11-03 Revised:2010-12-07 Online:2011-03-05 Published:2011-03-05
  • Contact: Yao Zhong-xiang, Professor, Doctoral supervisor, Department of Physiology, Basic Medical Department, Third Military Medical University of Chinese PLA, Chongqing 400038, China yaozhx@yahoo.com
  • About author:Li Jia-su, Squadron Four of Cadet Brigade, Third Military Medical University of Chinese PLA, Chongqing 400038, China jiasuli301@yahoo.com
  • Supported by:

    the National Natural Science Foundation of China, No. 31071056*

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Abstract:

BACKGROUND: Induced pluripotent stem cells (iPSCs) can differentiate into many kinds of expected neural cells to treat nervous system diseases which lack of neural cells, and play a relevant functional role. Recently, lots of encouraging progresses have been made. How to improve the efficiency and ensure graft substitute security, and be better applied to the clinical research has become a hot spot.
OBJECTIVE: To review the recent research and application of iPSCs in Parkinson’s disease, spinal cord injury, motor neuron disease and other nervous system diseases.
METHODS: We searched PubMed database (2006-01/2010-09) using “induced pluripotent stem cells, neurological diseases” as research words, and searched the Chinese Biomedical Literature Database (2006-01/2010-09) using “induced pluripotent stem cells” as the key words.
RESULTS AND CONCLUSION: A total of 149 articles on induced pluripotent stem cells were collected, including 17 Chinese articles, and 132 English articles. By reading the title and summary, articles that have nothing to do with this article and those with repetitive content were excluded. Finally, a total of 25 articles were reviewed. The iPSCs as a potential new treatment can be used as donor cells and diseases of the carrier, and have greatly potential value in Parkinson’s disease, spinal cord injury, muscular atrophy motor neurons and other nervous system diseases. Basic and clinical researches have made great achievements, but induction efficiency and transplantation safety are still major obstacles to its application and development.

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