Abstract:

BACKGROUND: In recent year, many research show the presence of panel reactive antibody and its sensitization degree have great significance with rejection reaction, graft survival and graft function realization.
OBJECTIVE: To investigate the difference of human leucocyte antigen (HLA) antibody incidence between old and youth uraemic patients.
METHODS: A total of 402 uraemic patients waiting for renal transplantation were selected, including 226 youth patients, 179 males and 47 females; and 176 old patients, 88 males and 88 females. All uraemic patients aged smaller than 35 or greater than 50 years old were analyzed. The serum HLA-IgG antibody in recipients was detected using ELISA. 
RESULTS AND CONCLUSION: Totally 14 patients showed PRA positive in the youth group, which was 32 in the old group, there was obviously difference (P < 0.005). In the youth group, 10 males and 4 females showed PRA positive, and there was no significant difference in PRA positive incidence between male and female patients (P < 0.05); in the old group, 10 males and 22 females showed PRA positive, with significant difference (P < 0.05). There is significant difference in PRA positive between old and youth group. The findings demonstrated that incidence of PRA in the old uraemic patients is greater than youth uraemic patients, and it shows great difference between males and females in old group.