Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 10049-10052.doi: 10.3969/j.issn.1673-8225.2010.53.041

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Infusion of bone marrow mesenchymal stem cells through transplanted renal artery in renal transplantation: A 3-case report

Xu Lu, Liao De-huai, Chen Zheng, Ma Jun-jie, Li Guang-hui, Fang Jia-li, Du Yang-chun, Bi Wen-hao, Pan Guang-hui   

  1. Department of Transplantation, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou  510260, Guangdong Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Pan Guang-hui, Chief physician, Department of Transplantation, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China panguanghui@126.com
  • About author:Xu Lu★, Studying for master’s degree, Department of Transplantation, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China tear-128@126.com

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) have emerged as a promising cell population for inducing immune tolerance. Currently, it is difficult to predict which route of administration is going to give the best clinical results for infusion of BMSCs in renal transplantation. Experiments in rats demonstrated that BMSCs injected into the renal artery retain in glomeruli and can reduce glomerulonephritis. No clinical experiments concerning infusion of BMSCs through transplanted renal artery were reported.
OBJECTIVE: To investigate the operability of infusing BMSCs directly into the transplanted renal artery.
METHODS: Three uremic patients with live donor kidney transplantation from Octobem 2009 to December 2009 were selected. During transplantation procedure, an indwelling needle was fixed at the renal artery stoma, which infusing BMSCs from transplanted renal artery directly to renal allograft when opening blood flow of transplanted kidney. Potential complications and the recovery of transplanted kidney were observed.
RESULTS AND CONCLUSION: The course of the operation was smoothly, without complications, such as embolism, infection, rejection and graft-versus-host disease in three months. The results demonstrated that it is feasible to infusion BMSCs to renal transplants from transplanted renal artery, but the long-term complications, such as ectopic differentiation or tumor, need to be further confirmed.

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