Abstract:

BACKGROUND: The people/renal survival rates have been improved greatly after renal transplantation, however, the long-term utilization of immunosuppressant enlarge the risk of malignancies.
OBJECTIVE: Combined with literatures to retrospective analyze the bladder malignancies following renal transplantation in 4 cases.
METHODS: Totally 4 cases with bladder malignancies following renal transplantation at the Department of Urinary Surgery, Zhongshan Hospital, Fudan University, from March 2007 to February 2008 were selected. All of them received triple immunosuppressive therapy after renal transplantation, including 3 females; mean aged 52.3 years when first diagnosed as bladder tumor, which was 7.3 years after renal transplantation. The cases were retrospective analyzed combined with literatures.
RESULTS AND CONCLUSION: Though bladder malignancy was rare following renal transplantation, it was still aroused increasing attention due to fast progression, easy recurrence and high malignancy. Follow-up for transplantation patients are necessary, ultrasonographic image examination should be performed once yearly, especially for those who appeared gross hematuria or microscopic hematuria. Early diagnosis and active treatment for bladder malignancy play an important role in the long-term survival of patients received renal transplantation.