Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 10011-10015.doi: 10.3969/j.issn.1673-8225.2010.53.032

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Vein graft materials: Progress in restenosis treatment following vein graft transplantation

Wang Wen-jun, Liu Ji-chun   

  1. Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Liu Ji-chun, Doctor, Chief physician, Professor, Doctoral supervisor, Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • About author:Wang Wen-jun★, Studying for master’s degree, Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China piaojunwen@sina.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30760247*, 30960380*

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Abstract:

BACKGROUND: It is may become a reality to prevent vein graft stenosis effectively with in-depth study of the mechanism of restenosis, further improvement of various treatment methods and the joint application.
OBJECTIVE: To introduce the multiple causes of vein graft lesions and to explore new method for the prevention of delayed vein graft stenosis.
METHODS: Using computer technology to retrieve the articles in VIP periodical full-text database, CNKI database, highwire full-text database and PubMed database published between January 1995 and December 2009 with key words of “heart surgery, vein transplantation, restenosis, prevention”. Literatures with regard to vein graft transplantation were included. Irrelevant and repetitive contents were excluded. Totally 40 literatures were selected for the further analysis. 
RESULTS AND CONCLUSION: Surgical coronary artery bypass graft surgery is the main treatment for the patients suffered from left main coronary artery and severe multi-vessel lesions. However, great saphenous vein is a kind of graft material, and the postoperative restenosis rate is relatively high, which brings a lot of inconvenience for the clinical treatment. This paper summarizes the multiple causes of vein graft lesions and to explore new method for preventing delayed vein graft stenosis from the aspects of conservative treatment, surgery prevention, extravascular stent, drug therapy, gene therapy and laser and radiation therapy.

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