Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 9950-9952.doi: 10.3969/j.issn.1673-8225.2010.53.017

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Antigenicity of freeze-dried irradiated pig dura mater

Zhang You-lai, Zeng Yuan-lin, Zou Li-jin, Xin Guo-hua   

  1. Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Zeng Yuan-lin, Professor, Chief physician, Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • About author:Zhang You-lai★, Master, Physician, Burn Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China youlaizhang@yahoo.cn

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Abstract:

BACKGROUND: Antigenicity is the main problem exists in allografts transplantation and decides the fate of transplantation.  
OBJECTIVE: To observe the antigen changes of freeze-dried irradiated pig dura mater.
METHODS: Freeze-dried porcine dura mater, irradiated porcine dura mater and freeze-dried and irradiated porcine dura mater were prepared by freeze-dried and (or) irradiated treatment and were transplanted into dura mater of white rabbits. Immunologic property was determined at 3 and 8 weeks after operation.
RESULTS AND CONCLUSION: There was no significant difference of lymphocytes death rates in the freeze-dried group and irradiated group (P > 0.05), both of which were greater than that of the freeze-dried irradiated group (P < 0.05). The results demonstrated that, the pig freeze-dried irradiated dura mater has low antigenicity.

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