Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 9937-9940.doi: 10.3969/j.issn.1673-8225.2010.53.014

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Correlation between early compaction and implantation potential on day 3 of fertilization

Zhang Bo, Yang Jing, Yin Tai-lang, Yan Wen-jie, Rumana Jafarey   

  1. Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Yang Jing, Doctor, Professor, Chief physician, Doctoral supervisor, Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China dryangqing@hotmail.com
  • About author:Zhang Bo☆, Studying for doctorate, Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China dramanda1222@yahoo.cn

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Abstract:

BACKGROUND: In spite of the fast development of the affiliated reproductive technology, the implantation rate of embryos is not very good. The correlation between early compaction and the implantation potential remains unclear. 
OBJECTIVE: To determine the correlation of early compaction on day 3 and the implantation rate.
METHODS: A total of 420 cases (1 016 embryos), who underwent controlled ovarian hyperstimulation and in vitro fertilization and embryo transfer were selected, and compared the implantation rate of day 3 embryos exhibiting early compaction and embryos without compaction.
RESULTS AND CONCLUSIONS: There were 200 embryos exhibiting early compaction, including 48 implanted embryos. At the same time, there were 816 embryos without early compaction, including 133 embryos implanted. There were significantly differences between two groups (P < 0.05). The pregnancy rate of the cases who received three compacted embryos was 71.43%, for those who received two compacted embryos was 31.91%, and those who received three compacted embryos was 51.06%, those who received non-compacted embryos was 39.81%. Accordingly, early compaction can notably increase implantation rate based on presently selection criteria of embryos. However, the precise mechanism still needs to be investigated.

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