Abstract:

BACKGROUND: During the perioperative period of lung transplantation, there is activation of blood coagulation and fibrionlytic system in extracorporeal circulation. But the research addressing function changes of blood coagulation during the perioperative off-pump period of lung transplantation is relatively rare.
OBJECTIVE: To detect the function changes of blood coagulation in recipient dogs during single lung transplantation.
METHODS: Twenty-four healthy male dogs were randomly divided into donor group and recipient group, followed by single lung transplantation. Activated clotting time (ACT), clotting rate (CR), and platelet function (PF) in the recipient group were detected with Sonoclot coagulometer respectively at 20 minutes after anesthesia induction (T1), 10 minutes before reperfusion (T2), 10 minutes after reperfusion (T3) and 60 minutes after reperfusion (T4).  
RESULTS AND CONCLUSION: Activated clotting time of T3 was obviously longer than T1, T2, and T4 (P < 0.001). CR and PF had no significant changes among the groups. These indicated that during the lung transplantation, activated clotting time was obviously prolonged 10 minutes after reperfusion, and returned to normal level one hour after reperfusion. CR and PF had no obvious changes at different time point.