Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 9893-9896.doi: 10.3969/j.issn.1673-8225.2010.53.003

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Effects of tracheal epithelial cells on obliterative bronchiolitis in a rat tracheal heterotopic transplantation model

Zhang Yu1, Liu Jian1, Chen Chang2, Han Biao1, Yang Zhen-hua1, Hu Xue-fei2   

  1. 1 Department of Thoracic Surgery, the First Affiliated Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China; 2 Department of Thoracic Surgery, Affiliated Pulmonary Hospital of Tongji University, Shanghai  200433, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Han Biao, Chief physician, Associate professor, Master’s supervisor, Department of Thoracic Surgery, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • About author:Zhang Yu★, Master, Department of Thoracic Surgery, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China keenan2006@hotmail.com

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Abstract:

BACKGROUND: Many studies have demonstrated that tracheal epithelial cells play a key role in chronic inflammation. The tracheal epithelium plays an immune response “target organ” effects, which can activate cellular and humoral immune response.
OBJECTIVE: To study the effects of tracheal epithelial cells on obliterative bronchiolitis in rat tracheal heterotopic transplantation.
METHODS: The rats were prepared for tracheal heterotopic transplantation models and randomly divided into 4 groups: epithelium group: Wistar rat tracheal model (donor) subcutaneous implanted in the back of SD rat (recipient). In the epithelium-removed group, the procedure was performed similar to epithelium group exception of this group had no epithelial cells. Control group 1: Wistar rat tracheal heterotopic transplantation model with sodium chloride, the model subcutaneous implanted in the back of Wistar rat (recipient). Control group 2: the same way with control group 1, however, the tracheal model had no epithelial cells. 
RESULTS AND CONCLUSION: The epithelium group occurred occlusion, and the occlusion rate was increased with time prolonged. There were no occlusions in the epithelium-removed group and control groups. The findings confirm that tracheal epithelial cells play an important role in the occurrence of bronchiolitis obliterans in a rat heterotopic tracheal transplantation model.

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