Abstract:

BACKGROUND: Vein graft restenosis and occlusion seriously affected postoperative long-term effect of coronary artery bypass grafting, which is the difficult medical problem to be solved at present.
OBJECTIVE: To review the therapeutic gene, vectors and transplanted pathway of gene therapy for vein graft restenosis.
METHODS: The relevant articles between January 1995 and July 2009 were retrieved from PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and database of Chinese knowledge (CNKI http://ckrd.cnki.net) using key words of “vein graft, gene, therapy”, and restricting the language as English and Chinese by computer. Literatures addressing therapeutic gene, vectors and transplanted pathway of gene therapy for vein graft restenosis were included. Old or duplicated studies were excluded.
RESULTS AND CONCLUSION: Vein graft restenosis seriously affected postoperative long-term effect of coronary artery bypass grafting. The traditional drug therapy brings little effect. Gene therapy can precisely target specific gene transfection to vascular wall and achieve the expression of exogenous gene, playing the maximum biological effect in the local, reducing systemic side effects. It is considered as a very promising approach. Gene therapy for vein graft restenosis will be broad prospects for development thank to its unique advantages. With the further study of the mechanism of restenosis and the appearance of safe and efficient vectors, the application of multi-gene therapy, drug therapy and physical therapy combination therapy will be the prevention of vein graft restenosis development.