Abstract:

BACKGROUND: Sertoli cell has become one of the research focuses in the fields of cell separation, tissue engineering and organ transplantation, and it has a promising application in clinical transplantation.
OBJECTIVE: To summarize the biological characteristics and research progress of sertoli cell at home and abroad.
METHODS: Articles addressing sertoli cell were retrieved from CNKI and Pubmed databases with the key words of “immune privilege, transplantation, function, progress of investigate” in both Chinese and English between January 1998 and October 2009. Articles in the same circle published in the authoritative journals or recently published were selected. There were 215 articles after the initial survey, and 34 articles related sertoli cell were included in the final analysis.
RESULTS AND CONCLUSION: Sertoli cell has the function of immune privilege and can secrete various nutrition factors. And it is widely drawn by providing new therapy for organ transplantation, Parkinson disease and diabetes mellitus. The research about sertoli cell has achieved a lot and presented an extremely captivating prospect in clinical field. It will make a great contribution to the clinical development of mankind. The clinical application of sertoli cell will be wider along with the development of transplantation of tissue engineering and organ transplantation.