Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (44): 8297-8302.doi: 10.3969/j.issn.1673-8225.2010.44.032

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Calcineurin inhibitors-induced nephrotoxicity: Early prevention and treatment following renal transplantation

Bao Ze-qing, Shi Lei, Zhao Shu-jin   

  1. Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou  510010, Guangdong Province, China　
  • Online:2010-10-29 Published:2010-10-29
  • Contact: Zhao Shu-jin, Professor, Doctoral supervisor, Chief physician, Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China gzzsjzhs@163.com
  • About author:Bao Ze-qing★, Studying for master’s degree, Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China zmj012@sohu.com
  • Supported by:

    the Plan for Social Development of Science and Technology Plan Project of Guangdong Province, No.2005B30701004*

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Abstract:

OBJECTIVE: To review the prevention and treatment for calcineurin inhibitors-induced nephrotoxicity.
METHODS: Using key words of “Ciclosporine A, Tacrolimus, CNIS drug-induced chronic nephrotoxicity”, documents published between January 1980 and January 2010 in databases of PubMed and CNKI were searched. Totally 44 articles closely related to calcineurin inhibitors-induced nephrotoxicity were reviewed.
RESULTS: Ciclosporin and tacrolimus were often employed as immunosuppressants, which notably improve life quality and survival rates of transplant recipients. However, long-term use of calcineurin inhibitors caused a characteristic type of chronic nephrotoxicity after renal transplantation and resulting in a decline of renal function. Currently, it has been confirmed that chronic allograft nephropathy and calcineurin inhibitors-induced nephrotoxicity are the main reasons for graft failure. The calcineurin inhibitors-induced nephrotoxicity plays an important role in natural course of chronic allograft nephropathy.
CONCLUSION: There is not an effective method for preventing or treating calcineurin inhibitors-induced nephrotoxicity. Thus, it may be a good choice for preventing calcineurin inhibitors-induced nephrotoxicity by reducing dose or withdraw of calcineurin inhibitors.

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