Abstract:

BACKGROUND: Clinical practice has confirmed that acute rejection is not rare during living renal transplantation. Steroid-resistant-induced rejection commonly occurs, and the clinical manifestation is not typical, so it is easy to do missed diagnosis and misdiagnosis. If severity, it will induce transplantation failure, and affect human/kidney long-term survival rate.
OBJECTIVE: To discuss clinical characteristics and prognosis of acute rejection in living renal transplantation
METHODS: Clinical date of 168 patients who received cadaver renal transplantation and 192 patients who received living renal transplantation from February 2005 to September 2008 were retrospectively analyzed, including clinical symptoms, complication and therapeutic outcomes. Acute rejection features of living renal transplantation were analyzed.
RESULTS AND CONCLUSION: The incidence of acute rejection and corticoid-resistent acute rejection in living and cadaver renal transplantation were 9.8%, 46.2 % and 22.8 %, 57.8% (P < 0.05). The symptoms of fever, hematuria, oliguria, transplanted renal pain and complication of infection, perirenal hematoma were less in acute rejection patients with living renal transplantation. All 19 cases of acute rejection with living renal transplantation were reversal; of 38 cases, 35 cases of acute rejection with cadaver renal transplantation were reversal; 2 cases transplanted renal fracture; 1 case with renal vein thrombus. Clinical analysis has indicated that the incidence of acute rejection and corticoid-resistent acute rejection in living renal transplantation were less than cadaver renal transplantation. Clinical symptoms were light, easy to reversal. But, the incidence of corticoid-resistent acute rejection in living renal transplantation was still high, so we must pay attention to kidney function and clinical symptom, and treated immediately.