Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (44): 8257-8260.doi: 10.3969/j.issn.1673-8225.2010.44.022

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Expression of transforming growth factor beta 1 in regenerated liver tissues following partial hepatectomy in rats

Song Hai-yan1, Gao Zhi-tao2, Liu Heng-xing1   

  1. 1 Department of Human Anatomy, 2 Research Center of Immunology, Xinxiang Medical University, Xinxiang  453003, Henan Province, China
  • Online:2010-10-29 Published:2010-10-29
  • Contact: Liu Heng-xing, Master, Professor, Department of Human Anatomy, Xinxiang Medical University, Xinxiang 453003, Henan Province, China liuhengxing@hotmail.com
  • About author:Song Hai-yan★, Master, Assistant lecturer, Department of Human Anatomy, Xinxiang Medical University, Xinxiang 453003, Henan Province, China shy80825@yahoo.com.cn
  • Supported by:

    the Scientific Research for High-level Talents in Xinxiang Medical University, No. 08SSKYQD-001*

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Abstract:

BACKGROUND: The safety of partial hepatectomy depends on the regeneration capacity of residual livers. Thus, it is significant to understand the liver regeneration following partial hepatectomy for patients with cirrhosis.
OBJECTIVE: To investigate the expression and significance of transforming growth factor-β1 (TGF-β1) in liver tissue of hepatic cirrhosis after partial hepatectomy in rats.
METHODS: The model of hepatic cirrhosis was made in control group and model group, and then partial hepatectomy was deployed as regeneration models. The expressions of TGF-β1 in liver tissues were determined by immunohistochemical methods and Western blotting 12, 24, and 72 hours after partial hepatectomy.
RESULTS AND CONCLUSION: There was no significant difference between the model and regeneration groups in the expression of TGF-β1 in liver tissues at 12 and 24 hours after partial hepatectomy (P > 0.05), but the expression of TGF-β1 was notably increased at 72 hours (P < 0.01). The findings demonstrated that the expression of TGF-β1 in liver tissue has no strong increase at the early stage after partial hepatectomy, which can promote liver regeneration mainly from the later stage interacted with other factors.

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