Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (44): 8203-8206.doi: 10.3969/j.issn.1673-8225.2010.44.009

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Detection of cytomegalovirus immediate early antigen in kidney and bone marrow transplantation recipients

Wu Guo-hua1, Luo Can-qiao1, Lai Ying-rong1, Liang Hui-zhen1, Zhong Jue-min1, Liang Ying-jie1, Wu Rong-pei2   

  1. 1 Department of Pathology, 2 Department of Urology Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China
  • Online:2010-10-29 Published:2010-10-29
  • About author:Wu Guo-hua, Technician-in-charge, Department of Pathology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China gzwgh@sohu.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 05300763*

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Abstract:

BACKGROUND: With the application of immunosuppressive agents, latent cytomegalovirus (CMV) will be activated following kidney or bone marrow transplantation. Therefore, accurate diagnosis of early CMV infection has great significance. The key point of controlling CMV infection is detecting the CMV replication in blood rapidly and quantitatively. 
OBJECTIVE: To detect CMV immediate early antigen in renal and bone marrow transplantation recipients and to explore its clinical diagnostic value. 
METHODS: The immediate early antigens of peripheral blood leukocytes with active CMV infection in 1 215 cases receive kidney and bone marrow transplantation were detected by immunohistochemistry.
RESULTS AND CONCLUSION: There were 492 cases (40.0%) with positive CMV immediate early antigen index and 723 cases with negative immediate early antigen index (60.0%), CMV IgG antibodies were significantly increased in 318 cases (26.0%), and CMV IgM antibody could be found in 90 cases (7.0%). CMV antigenemia detection technology exhibits highly sensitivity and specificity in diagnosing active CMV infection and has important prognostic significance in detecting CMV incidence, thus, it is an economical and viable diagnostic method.

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