Abstract:

BACKGROUND: According to its fine clinical results reported in recent years, ABO blood type in-compatible liver transplantation can be performed in order to shorten the time of waiting for donors, which gives this kind of patients the opportunity to receive liver transplantation and survive.
OBJECTIVE: To study the clinical effect and feasibility of ABO-incompatible liver transplantation.
METHODS: Data of 7 patients, who had performed ABO-incompatible liver transplantation in Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University from November 2005 to January 2010, were reviewed. Discussions were focused on the clinical effect and main complications and treatment measures improving, in order to analyze the feasibility of ABO-incompatible liver transplantation.
RESULTS AND CONCLUSION: There was bile duct stenosis in case 1 after operation. Bile exterior and interior pedestal drainage tube was set until cholangiography demonstrated that the bile duct was unobstructed and the drainage tube was removed 2 years later. Up to now there is no evidence of bile duct obstruct. Only case 4 died at five months postoperative due to the tumor metabases, other 6 patients survived well. Acute rejection was occurred in case 7 at 1 week postoperative on account of the abnormal rising of serum bilirubin level, urbason therapy was performed immediately and the serum bilirubin was decreased gradually to normal. There were no complications in other patients. ABO-incompatible liver transplantation is feasible for patients in emergency or other special conditions.