Abstract:

OBJECTIVE: To investigate the significance of inflammatory factors and cytokine levels to predict coronary stent restenosis.
METHODS: Using “coated coronary stent, restenosis, biocompatibility, inflammatory factor, cytokines” in Chinese as the key words, a computer search of Chinese CNKI Academic Database from January 2000 to December 2009 was performed. Articles related to inflammatory factors and cytokine levels in restenosis after coronary stenting were included, while repeated study or Mata analysis articles were excluded, 16 articles were selected for analysis.
RESULTS: Coronary stent implantation may lead to coronary artery injury, and promote in vivo cells to release inflammatory factors. After stent implantation, C-reactive protein, interleukin, tumor necrosis factor α and γ-interferon and other inflammatory factors and cytokines in peripheral blood have distinct expression, can reflect the local vascular injury and inflammation, as well as the applied stent biocompatibility after stenting.
CONCLUSION: The detection of inflammatory factors and cytokines in peripheral blood have predictive value on the in-stent restenosis, also reflect the stability of the atherosclerotic plaque in other parts, as feasible clinical observation index for the second level of coronary heart disease prevention after stenting.