Abstract:

OBJECTIVE: To evaluate the existing histocompatibility problems and application prospect of tissue engineering tendon constructed with different scaffold materials.
METHODS: Using “scaffolds, tissue engineering, tendon, histocompatibility” in Chinese and “support material; tissue engineering muscle tendon, tissue consistence” in English as the key words, a computer search was performed for articles between January 1994 and March 2010. Articles associated with the biomaterials and tissue engineered tendon were included; repeated study or Meta analysis articles were excluded. There are 32 articles main focusing existing histocompatibility problems and application prospect of the tissue engineering tendon constructed with different scaffold materials.
RESULTS: Tissue engineered tendon constructed in vitro has the strongest collagen synthesis capacity, it is currently considered as the optimal seed cells for in vitro construction of tissue engineered tendon. As for the materials, chitosan/poly(lactic-co-glycolic acid) emulsion film is an ideal material for tissue engineered tendon. Tendon tissues can be constructed in vitro using tissue engineering technology, cyclic stress may be more conducive to the formation of tendon tissue.
CONCLUSION: The present studies regarding tendon tissue engineering focus on two aspects, one is the source of tendon cells, and the other is scaffold biomaterials. The current research is a combination of a variety of materials and knitting methods, the scaffolds have good biocompatibility and the degradation rate is controllable, the scaffolds may degrade, while tendon cells proliferate and differentiate, and the desired biomechanical properties are gradually achieved, thus forming tendon tissue.