Abstract:

OBJECTIVE: To investigate the performance of chitin/chitosan biological antimicrobial dressings and their application in skin tissue engineering.
METHODS: China CNKI and Wangfang Medical network were searched on computer for articles about characteristics and clinical application of biological antibacterial dressings, retrieval time is from 1996 to 2010. Key words: biological antimicrobial dressings, chitin/chitosan, skin tissue engineering, security, performance in Chinese. Inclusion criteria: ①characteristics of chitin/chitosan biological antimicrobial dressings. ② application of chitin/chitosan biological antimicrobial dressing in skin tissue engineering. ③ articles recently published or published in the authority journals were preferred in the same field. Exclusion criteria: duplicated research and older literature were excluded. All data were checked preliminarily, and citations after each article were looked over.
RESULTS: According to the inclusion and exclusion criteria, 20 articles were included in the review. Chitin/chitosan has good security and degradation, strong moisture absorption and antibacterial property, it stops bleeding and pain, inhibits scar formation, promotes cell growth, accelerates wound healing and promotes non-specific immune function. From the application in skin tissue engineering research, chitin/chitosan is effective in promoting burn wound healing and skin regeneration, the probability of wound infection is not increasing.
CONCLUSION: Chitin/chitosan biological antimicrobial dressing has good performance, can effectively promote the burn wound healing and enhance skin regeneration, has a broad general application possibility in skin tissue engineering and other fields of medicine.