Abstract:

BACKGROUND: The strontium-doped hydroxyapatite can not only improve its degradation property, but also provide osteoinduction for hydroxyapatite materials, but strong acid phosphoric acid serves as the curing fluid in the preparation process, thus increase the acidity of strontium-doped hydroxyapatite.
OBJECTIVE: To study the pH value of gradient strontium-incorporated hydroxyapatite powders in biomimic situation.
METHODS: Standard buffer solution was prepared. Gradient strontium-incorporated hydroxyapatite powders with 0%, 1%, 5% and 10% strontium were fabricated using calcium phosphate bone cement through a hydration process. There were 6 parallel samples in each group, underwent ultraviolet radiation sterilization 3 hours. The leaching liquid was prepared at a ratio of strontium-incorporated hydroxyapatite powders: permeable medium = 1 g : 10 mL, placed in the incubator. The pH values of the gradient materials were measured at different time points.
RESULTS AND CONCLUSION: In the tests of pH value, all materials shown alkalescence. The gradient strontium-incorporated hydroxyapatite powders show a stable alkalescence in biomimic situation, they are beneficial for osteogenesis and internal environment stability.