Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (38): 7100-7102.doi: 10.3969/j.issn.1673-8225.2010.38.017

Previous Articles     Next Articles

Preparation of two kinds of new hydroxyapatite bio-composites

Yang Dong, Zhou Qi   

  1. College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an   710021, Shaanxi Province, China
  • Online:2010-09-17 Published:2010-09-17
  • About author:Yang Dong★, Master, Lecturer, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, Shaanxi Province, China yangdong@sust.edu.cn
  • Supported by:

    Special Science and Technology Program of Shaanxi Education Bureau, No.06JK338 *

PDF

303

Abstract:

BACKGROUND: In order to expand the application scope and practicality of hydroxyapatite, two different functional ultra-fine hydroxyapatite composites were prepared: silver-carrying hydroxyapatite and chitosan surface modified hydroxyapatite.
OBJECTIVE: To investigate antibacterial activity and stability of two new hydroxyapatite biocomposite.
METHODS: Using calcium hydroxide and calcium phosphate as the precursor, the hydroxyapatite was synthesized using homogeneous chemical precipitation method. Then silver-carrying hydroxyapatite and chitosan surface modified hydroxyapatite were prepared, antimicrobial activity of silver-carrying hydroxyapatite was determined using the inhibition zone test, the stability of chitosan surface modified hydroxyapatite was assayed through measuring the Zeta potential and average particle size.
RESULTS AND CONCLUSION: The hydroxyapatite at 1.2% silver loading had a strong antimicrobial effect on Escherichia coli and staphylococcus aureus, the inhibition zone diameters were 10 mm and 11 mm respectively; the surface charge of hydroxyapatite particles was influenced by pH value and the quantity of chitosan added, etc. The absolute value of Zeta potential would increase and the stability is enhanced at a range of pH value > 6.8 or < 6.8 and the quantity of chitosan added is certain (≤ 0.12%). The positively charged and stable hydroxyapatite aqueous suspension can be obtained by chitosan modification of hydroxyapatite particles.

CLC Number: