Abstract:

BACKGROUND: Sirolimus is a new generation of immunosuppressive agent with little renal toxicity, and it has been used effectively in Chinese kidney transplantation recipient patients to prevent acute rejection.
OBJECTIVE: To analyze the clinical characteristics and related factors of adverse drug reaction (ADRs) induced by immunosuppressive agent sirolimus following kidney transplantation.
METHODS: Retrieval-related contents were collected by computer from Chinese Journal Full-text Database in CNKI and Wanfang database with the key words of sirolimus and kidney transplantation during 2000 and 2009. ADRs cases induced by sirolimus reported in domestic medical journals were analyzed statistically by methods of bibliometries. The research thesis of sirolimus in clinical application and security were brought into the study, all ADRs cases must have detailed report in sex, age and ADRs syndromes. Reviews and simply reported literatures were excluded.
RESULTS AND CONCLUSION: A total of 15 literatures were selected and 500 patients were included. Of all the 468 ADRs cases, hyperlipidemia (182 cases, 38.9%) were the most frequent adverse reactions, other ADRs were infection and fever (62 cases, 13.2%), liver dysfunction (54 cases, 11.5%), etc. The most frequent adverse reactions were hyperlipidemia, infection and liver dysfunction. Regular drug monitoring and reasonably dose modulation may increase the validity and security of sirolimu