Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (31): 5737-5740.doi: 10.3969/j.issn.1673-8225.2010.31.010

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Hemostatic and coagulative variations of patients at perioperative period following living related liver transplantation

Song Li-jie1, Yao Gui-ling1, Liu Yu2, Zhao Yi-wen1, Ding Qi1, Cui Juan-hong1   

  1. 1 Department of Clinic Laboratory, 2 Department of Transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing  100039, China
  • Online:2010-07-30 Published:2010-07-30
  • Contact: Cui Juan-hong, Technician-in-charge, Department of Clinic Laboratory, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
  • About author:Song Li-jie★, Master, Associate chief technician, Department of Clinic Laboratory, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China sljdhl@sina.com

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Abstract:

BACKGROUND: The abnormality of hemostatic and coagulative indexes can result in serious complications, such as hemorrhage and thrombus, for patients following living related liver transplantation, however, the detail change laws remain poorly understood.
OBJECTIVE: To study the hemostatic and coagulative variations at perioperative period following living related liver transplantation.
METHODS: The venous blood were collected from 44 patients prior to and 1-7 days after living related liver transplantation. The dynamic changes of partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen contents, platelet, antithrombin activity, plasminonen activity, plasminogen activator inhibitor activity 1 (PAI-1), D-dimer, and fibrin degradation product were examined. Simultaneously, 32 healthy people were served as controls.
RESULT AND CONCLUSION: A prolongation of APTT, TT and PT were observed in patients prior to transplantation (P < 0.01). The platelet count, antithrombin activity, and plasminonen activity were reduced (P < 0.01), but the PAI- 1 was increased (P < 0.01). The PT, APTT, TT, platelet count, antithrombin activity, and antithrombin activity were recovered to normal level at 1 week after transplantation, but the levels of plasminonen activity, PAI-1, D-dimer, and fibrin degradation product were still abnormal. The results revealed that the coagulant and anticoagulant functions could be normal by successful operation and the recovery of fibrinolvtic functions were delayed, which are the main reasons for severe hemorrhage. Thus, the monitoring of coagulation and hemostatic function play an effective role in preventing hemorrhage and thrombosis.

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