Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (31): 5705-5708.doi: 10.3969/j.issn.1673-8225.2010.31.002

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Urinary neutrophil gelatinase-associated lipocalin and interleukin-18 in the predictive diagnosis of early graft disfunction following renal transplantation

Huo Wen-qian, Jin Feng-shuo, Nie Zhi-lin, Li Qian-sheng, Zhu Fang-qiang, Zhang Ke-qin   

  1. Department of Urinary Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing   400042, China
  • Online:2010-07-30 Published:2010-07-30
  • Contact: Zhang Ke-qin, Doctor, Associate professor, Department of Urinary Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing 400042, China zhkq2000@sina.com
  • About author:Huo Wen-qian★, Master, Attending physician, Department of Urinary Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing 400042, China huowenqian@yahoo.com.cn
  • Supported by:

    the Clinical Scientific Research Foundation of the Third Military Medical University of Chinese PLA, No. 2008XG182*

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Abstract:

BACKGROUND: Delayed renal graft function is a common complication of renal transplantation. Therefore, the predication etiological diagnosis is important for early treatment. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin (IL)-18 have been proved to be specific and susceptible markers for the diagnosis of acute renal tubule injury. However, the role of NGAL and IL-18 in the prediction or etiological diagnosis of early graft disfunction following renal transplantation remains uncertain.  
OBJECTIVE: To investigate the value of the urinary NGAL and IL-18 for the prediction or etiological diagnosis of early graft disfunction in renal transplantation.
METHODS: The urinary NGAL and IL-18 of the first 24 hours in 71 patients following renal transplantation were detected by enzyme linked immunosorbent assay (ELISA). The patients were divided into 2 groups including 41 cases of immediate graft function and 30 cases of graft disfunction. The graft disfunction group were subdivided into acute tubular necrosis (ATN, n=18) and acute rejection (AR, n=12) according to the origin of graft disfunction, and they were divided into slow graft function (SGF, n=16) and delayed graft function (DGF, n=14) according to the type of graft function. The clinical significance was evaluated by analyzing the correlation of urinary NGAL or IL-18 and the recovery of graft function.
RESULTS AND CONCLUSION: The urinary NGAL or IL-18 of all patients were significantly increased following renal transplantation, but the graft disfunction group was significantly greater than the immediate graft function group. For cases of graft disfunction, the level of IL-18 in AR group was significantly greater than ATN group (P < 0.01), but the level of NGAL was of no significant difference between the two groups (P > 0.05). However the level of NGAL of SGF group was significantly greater than the DGF group (P < 0.01), and the level of IL-18 was similar in the two groups (P > 0.05). Results show that urinary NGAL and IL-18 are useful for predicting the early graft function after renal transplantation. Moreover, high urinary IL-18 can help to the diagnosis of AR and high NGAL may suggest the recovery capability of graft function.

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