Abstract:

BACKGROUND: Some patients with coagulation disorders and substantiality abdomen viscera trauma cannot stop bleeding when using conventional surgical techniques alone, so the biomedical research and clinical application of absorbable hemostatic materials have been rapidly developed.
OBJECTIVE: To review the research status of clinical absorbable hemostatic materials in recent years, and to provide guidance to clinicians.
METHODS: The database of PubMed and CNKI from February 2000 to February 2010 was retrieved on computer using key words of “biomaterial, hemostatic material, bioresorbable material, hemostasis effect, hemostatic mechanism”. The literature was limited to English and Chinese languages. Literatures concerning application of biomedical absorbable hemostatic materials were included, consisting of reviews and clinical experiments. Other papers about duplicated study and contents inconsistent with the research purpose were excluded.
RESULTS AND CONCLUSION: Based on literature review, the bioabresorbable hemostasis materials include fibrin glue, oxidized regenerated cellulose and oxidized cellulose, α-cyano-acrylate tissue adhesive, abresorbable gelatin sponge, microfiber collagen. Different hemostatic materials are varied in the hemostatic mechanism and hemostatic effect, only fully understanding the performance of various hemostatic materials can achieve very efficient outcomes in clinical practice.