Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (21): 3969-3972.doi: 10.3969/j.issn.1673-8225.2010.21.041

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Research and advances of drug nanocapsule system carrier in orthopedic field

Zhu Xiao-fei, Sheng Wen-bo, Su Jia-can   

  1. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai  200433, China
  • Online:2010-05-21 Published:2010-05-21
  • Contact: Su Jia-can, Doctor, Associate chief physician, Associate professor, Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China sujiacan@yahoo.com.cn
  • About author:Zhu Xiao-fei, Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China zhuxiaofei_zxf@163.com
  • Supported by:

     the Grant from Shanghai Science and Technology Commission for Nanometer, No. 0852nm04300*; the Specific Foundation of Shanghai Health Bureau, No. 2009S018*; the Talent Development Foundation of Shanghai Personnel Bureau*; the Scientific Research Foundation for Outstanding Young Teachers of Shanghai Institutes*

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Abstract:

BACKGROUND: Drug nanocapsule system carrier is the fundament of maximizing drug effect. It is now documented that drug nanocapsule system carrier can not only load drug or drug-loaded nanocapsules but also be a scaffold for the repair of bone defect and bone regeneration.
OBJECTIVE: To review current situation of drug nanocapsule system carrier in orthopedics.
METHODS: A computer-based online search of Elsevier (http://www.sciencedirect.com/) and VIP (http://202.121.226.3/index.asp) was performed for English and Chinese articles with all the key words “drug nanocapsule, delivery, calcium phosphate cement, bone cement, titanium, coral hydroxyapatite, nano-hydroxyapatite/collagen, antibiotic/antibiotics, bone defect, bone regeneration” in English and Chinese. Inclusive criteria: Researches about drug nanocapsule system carrier in treating infection, bone defect repair and bone regeneration facilitation. Irrelevant or repetitive articles were excluded.
RESULTS AND CONCLUSION: Drug nanocapsule system carrier is an ideal vehicle for medicine. Compared with traditional drug administration, it controls release of medicine and concentrates medicine in a focus. So when it carries growth factor or medicine, it can maximize the effect with minimal dose. However, it is under exploration, and questions require further validation as to its interaction with human body and effect on bioactivity of medicine.

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