Abstract:

OBJECTIVE: To investigate the safety and effectiveness of artificial ligament surface modification in anterior cruciate ligament reconstruction.
METHODS: Using “artificial ligament, scaffolds, cruciate ligament, reconstruction” as the search word, an electric retrieval was performed in the Chinese Journal Full-text database (CNKI: 1990/2010). In vitro studies and animal experiments were summarized and analyzed, clinical comparative study was analyzed using Review Manager4.2 software.
RESULTS: Five out of 16 in vitro studies were involved in the analysis, showing various forms of surface modification can achieve good biological properties and tissue compatibility of artificial ligament. Four out of 19 animal experiments show that, surface modified artificial ligaments also exhibit biological functions in animals and then achieve the goal of joint function restoration. Five out of 57 clinical comparative analysis were demonstrated by Meta analysis, there were differences between the artificial ligament reconstruction group and the non-artificial ligament reconstruction group, but not statistically significant (P = 0.40), the RR value and 95%CI of 5 test articles were 1.10 (-1.01, 3.21), 6.80 (4.10, 9.50), -0.66 (-1.16, 0.16), 8.06 (5.17, 10.95), 4.18 (2.48, 5.88), respectively, the combined RR values and 95%CI was 0.20 (-0.26, 0.65).
CONCLUSION: The surface modified artificial ligament shows good biocompatibility and safety for anterior cruciate ligament reconstruction, and can obtain similar clinical effects in allogeneic or autologous transplantation.