Abstract:

OBJECTIVE: To evaluate the effects of different biological materials to prevent the adhesion between tendon and tendon sheath following sports injury repair and to search for a suitable biological material.
METHODS: Using “biological materials, tendon injury, postoperative adhesions, clinical application” in Chinese and “biological materials, tendon injury, conglutination” in English as the key words, a computer search was performed for articles published between January 1990 and December 2009. Articles related to the biological materials and tissue engineering femoral defects were included; repeated study or Meta analysis articles were excluded.
RESULTS: Following tendon injury, the common complications are tendon adhesion, while tendon adhesion or joint adhesion is common after fracture or joint injury, its prevention and treatment has been a general concern in the medical field. Currently applied approach by domestic and foreign scholars is polymers and drug barrier in the prevention of tendon adhesion. Chitosan, hyaluronic acid and poly-DL-lactic acid film are mostly used and mature technology in the clinical application, achieving satisfactory treatment effect. 5-fluorouracil and fibrin glue are also seen in the clinical treatment, with remarkable effects. Other drugs or materials such as gold foil, collagenase and glycerol mixture, are not seen in the current clinical application and only limited to animal models, they showed obvious outcomes for the prevention of tendon adhesion in animal experiments.
CONCLUSION: The scientific and rational combination of various drugs or high-tech biological materials to prevent adhesions after tendon injury will be the future direction of medical development.