Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (21): 3919-3922.doi: 10.3969/j.issn.1673-8225.2010.21.028

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Knee ligament injury and artificial ligament

Wang Feng   

  1. College of Physical Education, Henan Polytechnic University, Jiaozuo   454000, Henan Province, China
  • Online:2010-05-21 Published:2010-05-21
  • About author:Wang Feng★, Master, College of Physical Education, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China

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Abstract:

OBJECTIVE: To classify and summarize the approaches of artificial materials for rehabilitation and treatment of knee ligament injury, to investigate biological material rehabilitation intervention and treatment means of artificial knee injury and the underlying mechanisms, as well as the research focuses.
METHODS: A computer search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) was performed by the first author, using “knee joints, ligaments” in Chinese or “Knee, ligament” in English as key words in the titles and abstracts. Articles related to knee ligament treatment approach, materials science characteristics, biocompatibility and its application effect were included, these articles recently published or published in the authorized magazine were preferred for the same field. Totally 28 literatures were included.
RESULTS: The anterior cruciate ligament tissue engineering is the hotspots of current study, a large number of researches have been conducted regarding the choice and construction methods of scaffold materials, the isolation and culture methods of seed cells, and the application of cell factor and surface modification. Now in vitro experiments and biomechanical experiments have achieved good results, but there are still a lot of questions. With advancements in the cell biology and molecular biology methods and technology, tendon ligament injury repair has processed into a new stage, also achieving great progress. The rise of tissue engineering provides an effective way for ligament.
CONCLUSION: In anterior and posterior cruciate ligament reconstruction, autologous graft is still the best choice, but the artificial ligament also demonstrates its unique advantages. Although artificial ligament has deficiencies and is not ideal enough to completely replace the cruciate ligament, artificial ligament really provides a choice for anterior and posterior cruciate ligament reconstruction, it is an important step in the history of cruciate ligament reconstruction.

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