Abstract:

BACKGROUND: There are some problems such as high inflammatory reaction and low biocompatibility although some progressive achievements have been obtained in the research of bone and cartilage tissue engineering. Technology of composite scaffold is an important method to dissolve the problems.
OBJECTIVE: To fabricate CaCO3 / calcium polyphosphate / poly-(L-Lactic acid) (CaCO3/CPP/PLLA) composite tissue engineered scaffolds.
METHODS: The ball milling CaCO3/CPP/PLLA composite tissue engineered scaffolds were fabricated with a solvent-casting, particulate-leaching and gas foaming methods. The properties of physical mechanics and degradation rates in vitro were tested. The microstructure of cross section of scaffold composites was observed by scanning electron microscope.
RRSULTS AND CONCLUSION: The ball milling CaCO3/CPP/PLLA composite tissue engineered scaffolds were fabricated with the porosity of scaffolds varying 60% and 80%, which has three dimensional, interconnect, micro-hole network structure. Its density of experimental data was basically coincident with its calculated data. The compressive modulus was more than 3 MPa and it met the requirements of composite tissue engineered scaffolds. The degrade rate was increased with the prolonging of the degradable times. The degradable liquid pH value was maintained between 6 and 7.5. The degradable liquid pH value was stabled with the addition of the powder ball milling CaCO3. The microstructure of scaffold composites still has three dimensional interconnect micro-hole network structure after degrading.