Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (4): 633-636.doi: 10.3969/j.issn.1673-8225.2010.04.014

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Correlation between noise and fluorescence molecular tomography based on the adaptive-mesh-based algorithm using an analytical solution

Wang Dai-fa, Zhang Tao, Bai Jing   

  1. Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China
  • Online:2010-01-22 Published:2010-01-22
  • Contact: Bai Jing, Professor, Doctoral supervisor, Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China deabj@tsinghua.edu.cn
  • About author:Wang Dai-fa☆, Doctor, Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing 100084, China wdf@mails.tsinghua.edu.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30670577*, 60831003*, 30930092*, 30872633*; the Tsinghua-Yue-Yuen Medical Science Foundation*; the National Basic Research Program of China (the 973 Program), No. 2006CB705700*; the Hi-Tech Research and Development Program of China (the 863 Program), No. 2006AA020803*; the Special Research Fund for the Doctoral Program of Higher Education of China*

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Abstract:

BACKGROUND: Fluorescence molecular tomography (FMT) has become a fast developing molecular imaging technique. Noise is a challenge for FMT, and the influence of noise on molecular imaging remains unclear.
OBJECTIVE: To investigate the influence of noise on imaging reconstruction based on the adaptive-mesh-based algorithm using an analytical solution.
METHODS: In this paper, the influence of noise on FMT was studied based on the adaptive-mesh-based algorithm using an analytical solution.
RESULTS AND CONCLUSION: By adding noise to the simulated data, the reconstruction results with different signal-to-noise ratio are obtained and discussed. The experiment results show that the adaptive-mesh-based algorithm is robust in the existence of noise.

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