Chinese Journal of Tissue Engineering Research ›› 2025, Vol. 29 ›› Issue (1): 1-7.doi: 10.12307/2024.733
Kong Dai, Wang Xinkai, Zhang Wenhui, Pei Xiaohang, Lian Cheng, Niu Xiaona, Guo Honggang, Niu Junwei, Zhu Zunmin, Liu Zhongwen
Received:
2023-10-17
Accepted:
2023-11-21
Online:
2025-01-08
Published:
2024-05-17
Contact:
Liu Zhongwen, MD, Chief physician, Department of Hematology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
About author:
Kong Dai, Master, Attending physician, Department of Hematology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Supported by:
CLC Number:
Kong Dai, Wang Xinkai, Zhang Wenhui, Pei Xiaohang, Lian Cheng, Niu Xiaona, Guo Honggang, Niu Junwei, Zhu Zunmin, Liu Zhongwen. Oral Herombopag Olamine and subcutaneous recombinant human thrombopoietin after haploidentical hematopoietic stem cell transplantation[J]. Chinese Journal of Tissue Engineering Research, 2025, 29(1): 1-7.
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2.4 造血重建情况 经植活鉴定,空白对照组、rhTPO 组 及海曲泊帕组分别有 2 例、2 例、1 例出现原发植入失败, 植 入 成 功 率 分 别 为 96.88%,97.22%,96.30%, 差 异无显著性意义 (P=1.000)。中性粒细胞植入时间分别为 (12.95±3.88) d、(14.04±3.71) d、(13.89±2.74) d, 差 异 无 显著性意义 (P=0.352);血小板植入时间分别为 (15.16± 6.27) d、(17.67±6.52) d、(17.00±4.75) d,差异无显著性意 义 (P=0.287)。第 60 天对血小板完全植入率进行统计, 空白对照组、rhTPO 组及海曲泊帕组分别为 64.06%, 90.28%,92.59%,差异有显著性意义 (P < 0.001),随后进 行亚组分析,空白对照组与 rhTPO 组比差异有显著性意 义 (P < 0.001),空白对照组与海曲泊帕组比差异有显著性 意义 (P=0.004),rhTPO 组与海曲泊帕组比差异无显著性意 义 (P=0.535),见表 3。 2.5 急性移植物抗宿主病发生率 对 100 d Ⅱ - Ⅳ度急 性移植物抗宿主病发生率进行统计分析,空白对照组、 rhTPO 组、海曲泊帕组分别为 25.00%,30.56%,25.93%, 差异无显著性意义 (P=0.752),见表 3。"
2.6 巨细胞病毒感染及巨细胞病毒肺炎发生情况 对随 访期内巨细胞病毒血症发生率进行统计,空白对照组、 rhTPO 组、海曲泊帕组分别为 40.63%,36.11%,29.63%, 差异无显著性意义 (P=0.602);3 组分别有 3 例、3 例、1 例患者进展为巨细胞病毒肺炎,发生率为 4.69%,4.17%, 3.70%,差异无显著性意义 (P=1.000),见表 3。 2.7 肝功能损伤发生率 对 3 组患者 30 d 内肝功能损伤 进行统计分析,空白对照组、rhTPO 组、海曲泊帕组发生 率分别为 23.44%,20.83%,22.22%,差异无显著性意义 (P=0.935),均为Ⅰ - Ⅱ度肝功能损伤,经应用保肝药物后 实验室指标异常迅速消失,对后续用药未造成影响,见 表 3。 2.8 血栓 随访期内,3 组患者均无血栓事件发生。 2.9 复发与生存情况 随访 1 年节点对 3 组患者的生存率 进行统计分析,空白对照组、rhTPO 组、海曲泊帕组分别 为 73.44%,76.39%,81.48%,差异无显著性意义 (P=0.711)。 随访 1 年节点对 3 组患者的复发率进行统计分析,空白对 照组、rhTPO 组、海曲泊帕组分别为 12.50%,11.11%, 14.81%,差异无显著性意义 (P=0.858)。对 3 组患者 1 年 累积生存率进行 Kaplan-Meier 分析,差异无显著性意义 (P=0.809),见表 3,图 2。 "
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