The relationship between postmenopausal bone mineral density and specific physiological period values in women based on NHANES database

doi:10.12307/2023.811

Abstract

Abstract: BACKGROUND: Clarifying the exact relationship between specific physiological periods and postmenopausal low bone mineral density in women can be a key to predicting low bone mineral density in postmenopausal women and provide a reference value for preventing the occurrence of low bone mineral density.
OBJECTIVE: To investigate the association between different special periods and postmenopausal low bone mineral density in women.
METHODS: A total of 15 560 samples were collected from the NHANES database (published from 2017 to 2020), and 1 563 participants were screened out. Their bone mineral density values were acquired to calculate the T-score. Those with osteoporosis and osteopenia were enrolled in observation group, while those with normal bone mass acted as controls. Three linear regression models were established to evaluate the effects of age at menarche, age at menopause, gravidity and parity on postmenopausal low bone mineral density. Finally, the results of multivariate logistic regression analyses were used to verify the relationship among gravidity, parity and low bone mineral density.
RESULTS AND CONCLUSION: The incidence of postmenopausal low bone mineral density was 1.62 times higher in participants aged > 13 years at menarche than those aged < 12 years at menarche. Relative to menopausal age under 45, the odds ratio value for postmenopausal low bone mineral density was 0.72 for those between 45-55 years of age at menopause and 0.51 for those over 55 years of age at menopause. Gravidity was negatively correlated with the T scores of the femur and greater trochanter but showed no correlation with the T score of the lumbar spine. Parity was not related to the T scores of the femur and lumbar spine but only negatively related to the T score of the greater trochanter. The later the age of menarche, the earlier the age of menopause, the more pregnancies, the greater the likelihood of postmenopausal lower bone mineral density. Gravidity has the most significant effect on the bone mineral density of the femur and greater trochanter.

Key words: physiological period, age at menarche, age at menopause, gravidity, parity, bone mineral density

CLC Number:

Yang Yunhong, Fan Yinuo, Zhang Jiahao, Zhang Xiangqi, Zhao Xiaofeng, Chen Zhenqiu, Sun Xiaofeng. The relationship between postmenopausal bone mineral density and specific physiological period values in women based on NHANES database[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(32): 5191-5195.

Figures/Tables 2

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